Scientists of Tyumen Cardiology Center obtained 2 patents on up-to-date methods

Co-author of the first paper Anna Soldatova, MD, scientific researcher of laboratory of instrumental diagnostics of Tyumen Cardiology Center told that over the last 20 years recommendations for selection for cardiac resynchronization therapy significantly changed. All of them are aimed at reducing the number of patients who "do not respond" or "respond" insufficiently to the therapy. However, there are patients with good survival rates, and in some cases, positive effects after CRT allow them to return to work.

The method of predicting super-response is based on the results of standard set of analysis for all patients with chronic heart failure in selection for cardiac resynchronization therapy, such as echocardiography, clinical and laboratory examinations with evaluation pro-brain natriuretic peptide (NT-proBNP) levels. The method does not require special conditions or additional costs, it is time-efficient and easy to conduct, but at the same time it is highly effective in predicting the best response to CRT for each patient.Due to high cost of the therapy, the relevance of scientific researches in this field has a very high value and the possibility of predicting response to CRT allows to conduct a more careful selection.

Inventors: Vadim A. Kuznetsov, Anna M. Soldatova, Dmitriy V. Krinochkin, Tatyana N. Enina, Tatyana I. Petelina, Aleksandr Yu. Rychkov, Nikolay N. Melnikov.

The second patented method is designed to solve the problem of high prevalence of arterial hypertension in the Arctic. One of the authors Nina Shurkevich, MD, PhD, Senior Scientific Researcher, a cardiologist of the Department of Arterial Hypertension explained: «Based on one-year follow-up and analysis of the association between blood pressure fluctuations and the time of day we identified the risk factor for hypertension in men of working age in the conditions of monthly shiftwork in the Arctic». The research will help to improve early diagnostics of arterial hypertension.An eight-year study included more than 800 men aged 20 to 59 years working a rotating shift schedule in the Arctic conditions.

Scientists determined the risk of development of arterial hypertension and designed preventive measures for those patients in the high-risk category using the analysis of 24-hour blood pressure monitoring results and special mathematical formula. The method also allows to assess the risk of the disease at the earliest stages and since arterial hypertension is a major cause of severe complications and mortality, the medico-social significance of improving early diagnosis of the disease is obvious.

Inventors: Alexander S. Vetoshkin, Nina P. Shurkevich, Ludmila I. Gapon, Denis G. Gubin, Sergey M. Diachkov, Fedor A. Poshinov, Nataliya V. Shipitsyna.